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Titanium Sterilization Tank

Before the medium is sterilized, it is usually sterilized by the fermented tank air filter and blow dry with the air. After feeding, start stirring to prevent precipitation. Then turn on the fixture steam valve, slowly introduce the steam, so that the ingredients are warmed to about 80℃ and turn off the fixture steam valve. Open the three roads (air, disbursement, sampling) into the auto valve, and open the auto valve. When the temperature rises to 110℃, control the in-entry and exit valve until 121℃ (table voltage 0.1 ~ 0.15MPa), and start thermal insulation, generally heat preservation for 20 minutes. After the heat preservation, turn off the filter exhaust valve and the steam valve. Turn off the sewer valve and turn on the cooling water into the water return valve. When the tank is lower than the pressure of the filter, turn on the air intake valve and introduce sterile air. Then cooling water to reduce the temperature of the medium to the cultivation temperature. 

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The Titanium Coil Heat Exchanger is specifically designed for pharmaceutical sterilization processes involving betaine solutions. Manufactured entirely from Grade 2 titanium, the equipment provides outstanding corrosion resistance, excellent heat transfer performance, and long-term operational reliability in demanding pharmaceutical environments.

Titanium's superior resistance to organic acids, alkaline solutions, inorganic salts, and various chemical compounds makes it an ideal material for sterilization systems where purity, cleanliness, and equipment longevity are critical.

The unit utilizes a coiled tube design that maximizes heat transfer efficiency while maintaining compact equipment dimensions, making it suitable for continuous pharmaceutical production lines.

Typical Application

Pharmaceutical Industry

  1. Betaine sterilization systems

  2. Pharmaceutical intermediate processing

  3. Biochemical production

  4. Sterile liquid heating and cooling

  5. Corrosion-resistant process systems

Technical Specifications

ParameterSpecification
ApplicationBetaine Sterilization
Heat Exchanger TypeTitanium Coil Heat Exchanger
Tube MaterialTitanium Grade 2
Shell MaterialTitanium Grade 2
Heat Transfer Area12.4 m²
Equipment Weight2,780 kg
Tube Side MediumCirculating Water
Shell Side MediumBetaine
Tube Side Design Pressure0.09 MPa
Shell Side Design Pressure0.09 MPa
Tube Side Working Pressure0.05 MPa
Shell Side Working Pressure0.05 MPa
Hydrostatic Test Pressure0.44 MPa
Tube Side Design Temperature10 – 30°C
Shell Side Design Temperature10 – 130°C

Working Principle

The heat exchanger transfers thermal energy between circulating water flowing through the titanium coil tubes and the betaine solution contained within the shell.

During operation:

  1. Circulating water flows through the titanium coil.

  2. Betaine solution flows through the shell side.

  3. Heat is transferred through the titanium tube walls.

  4. The required sterilization temperature is achieved and maintained.

  5. Process temperature remains stable through continuous heat exchange.

The coiled tube configuration increases the heat transfer surface area and promotes efficient thermal exchange while minimizing equipment footprint.

Why Titanium for Pharmaceutical Heat Exchangers?

Titanium Grade 2 offers a unique combination of corrosion resistance, mechanical strength, and process reliability.

Excellent Corrosion Resistance

Titanium performs exceptionally well in:

  1. Organic acids

  2. Alkaline solutions

  3. Inorganic salts

  4. Pharmaceutical intermediates

  5. Chemical processing fluids

Long Service Life

Unlike conventional stainless steel equipment, titanium maintains excellent performance even under prolonged exposure to corrosive media.

High Purity Processing

Titanium does not contaminate process fluids, making it ideal for pharmaceutical and biotechnology applications where product purity is critical.

Lightweight Construction

Titanium provides high strength with lower density, reducing overall equipment weight while maintaining structural integrity.

Key Features

Fully Titanium Construction

Both shell and coil tubes are manufactured from Grade 2 titanium, ensuring maximum corrosion resistance throughout the entire system.

Efficient Heat Transfer

The coiled tube design provides:

  1. Large heat transfer surface area

  2. Enhanced thermal efficiency

  3. Uniform temperature distribution

  4. Compact equipment layout

Pharmaceutical-Grade Reliability

Suitable for:

  1. Continuous operation

  2. Sterilization processes

  3. Clean process environments

  4. Long-term service

Low Maintenance Requirements

Titanium's resistance to corrosion and scaling significantly reduces maintenance frequency and operating costs.

Material Options

Standard Configuration

Shell: Titanium Grade 2

Coil Tube: Titanium Grade 2

Optional Materials

Depending on process conditions, alternative titanium grades can be supplied:

MaterialCharacteristics
Grade 2 TitaniumGeneral corrosion resistance
Grade 7 TitaniumEnhanced resistance to reducing acids
Grade 12 TitaniumImproved strength and corrosion resistance

Design Advantages

Corrosion Protection

Titanium provides exceptional resistance against process media commonly found in pharmaceutical and chemical industries.

Thermal Efficiency

The coil configuration improves heat transfer effectiveness while maintaining stable process temperatures.

Operational Safety

Designed according to pressure vessel requirements with hydrostatic testing performed at 0.44 MPa.

Process Stability

Maintains consistent sterilization conditions and reliable heat transfer performance.

Inspection & Quality Control

Each heat exchanger undergoes strict quality control procedures, including:

  1. Raw material certification

  2. Welding inspection

  3. Dimensional inspection

  4. Hydrostatic pressure testing

  5. Leak testing

  6. Surface quality inspection

  7. Final performance verification

Maintenance Recommendations

Routine Inspection

Visual inspection of titanium surfaces

Monitoring for fouling or scaling

Verification of operating pressures and temperatures

Cleaning

Periodic cleaning helps maintain maximum heat transfer efficiency. Non-abrasive cleaning methods are recommended to preserve the titanium surface.

Leak Detection

Regular inspection of seals, flanges, and connections ensures long-term operational reliability.

Applications Beyond Betaine Sterilization

Titanium coil heat exchangers are widely used in:

Pharmaceutical Industry

  • Sterilization systems

  • Drug manufacturing

  • Bioprocessing

Chemical Industry

  • Corrosive chemical heating

  • Acid and alkali processing

  • Specialty chemical production

Food & Beverage Industry

  • Hygienic heat transfer systems

  • Process cooling and heating

Environmental Systems

  • Wastewater treatment

  • Chemical dosing systems



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Changsheng Titanium Offers Wide Ranges of Titanium Products and Alloys
Changsheng Titanium Offers Wide Ranges of Titanium Products and Alloys
No.26 Baotai Road, Weibin District, Baoji City, Shaanxi, China.
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